Optimized Markov state models for metastable systems

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Optimized Markov state models for metastable systems.

A method is proposed to identify target states that optimize a metastability index amongst a set of trial states and use these target states as milestones (or core sets) to build Markov State Models (MSMs). If the optimized metastability index is small, this automatically guarantees the accuracy of the MSM, in the sense that the transitions between the target milestones is indeed approximately ...

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Review Markov processes with a unique stationary distribution on large state spaces are considered. The task of obtaining a low-dimensional approximate description of the slow-scale dynamics has been treated by many authors with various applications in mind. In this paper Markov state models (MSMs) are reviewed, with the typical setup being a continuous state space and a metastable stochastic p...

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ژورنال

عنوان ژورنال: The Journal of Chemical Physics

سال: 2016

ISSN: 0021-9606,1089-7690

DOI: 10.1063/1.4954769